Invasive Physiology Monitoring
TeleMetronics Biomedical is the main contractor of the project “Invasive Physiology Monitoring for Mouse”, commissioned by the European Space Agency (ESA). TeleMetronics develops an innovative mouse telemetry system to monitor physiological signals of each individual mouse like heart rate, ECG, blood pressure, cardiac output and body temperature. The mouse telemetry system can be used in the ESA Mouse in Space (MiS) project. In this project ESA prepares and develops all the necessary hardware and software for a satellite flight of 32 mice for 45 days. Subcontractors in this project are: Noldus Information Technology, Mans RF Design, Skedio Circuits, Penguin Programs and Delft University of Technology (Electronic Instrumentation Laboratory).
TeleMetronics Biomedical is one of the 8 partners in a consortium that aims to develop a novel system for the automated assessment of wellbeing of rodents in a home cage environment. The SenseWell proposal was one of the winners of the “IIP Cooperation Challenge”, a program launched by the Dutch national authority for ICT research (“ICTRegie”) to stimulate ICT-based innovation in domains ranging from brain and cognition research to sensor networks and robotics. The general aim of SenseWell is to develop an automated system for the early detection of symptoms of disease and chronic stress in order to assess health and wellbeing in socially housed rodents. This rodent model will serve as basis for a system in animal husbandry practice in which it can support the management of large numbers of animals as is the case in for example pig stables. Within the project, TeleMetronics will integrate the PhysioLinq system in PhenoTyper cages with software for video tracking and behavior recognition (EthoVision) and detection of ultrasonic vocalizations (Sonotrack). Partners in this project are academic groups from Utrecht, Wageningen and Delft and three companies (Noldus Information Technology, Delta Phenomics and Metris).
- PhysioGear: development of a wireless blood flow meter, in collaboration with Transonic Systems Inc. (Ithaca, NY, USA)
- S.T.A.R. (Space Telemetry for Animal Research): development of a mouse telemetry system for the European Space Agency (ESA)
- M.O.T. (MOuse Telemetry): development of an accelerometer test device for the Dutch Delta Mission of André Kuipers, for the European Space Agency (ESA)
- LST for MIS (Life Science Technology for Mouse in Space): development of a second generation mouse telemetry system for ESA
- TIR (Tele-Injection in Rodents): a feasibility study of an automated micro-infusion pump system for use in mice, for ESA
- Blood pressure implants: joint development with Millar Instruments, Inc. (Houston, TX, USA) and funded by the National Institute of Health, to integrate Millar’s sensor technology into TeleMetronics telemetry systems.